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Prolific PL-2303 driver Device Cannot Start Windows Vista 64bit and Windows 7

Greenwire® > IT Tech Support Articles  > Prolific PL-2303 driver Device Cannot Start Windows Vista 64bit and Windows 7

Prolific PL-2303 driver Device Cannot Start Windows Vista 64bit and Windows 7

I was working on this problem for one of our Fort Myers Business Tech Support Clients, but I’ve had this problem a couple times and the solution seems to be slightly different each time.  The problem presents itself as a Device in Device Manager showing “”The Device Cannot Start (Code 10)” after you’ve installed the Prolific PL-2303 Drivers from the Prolific website. Which are available here: http://www.prolific.com.tw/eng/downloads.asp?ID=31

The solution is to use a similar driver set floating around on the internet here: http://www.usglobalsat.com/download/546/win_drivers.zip

Unzip the file and install the executable within. That fix solved the problem for me instantly. To make sure that the new driver take priority over the other one in Windows 7 right click on the device and go to Unistall and check “Delete the driver software for this device”. I found this solution on the microsoft social forums here.

Greenwire Technology Solutions
  • Posted at 2:42 am, October 22, 2009

    great solution it is working in Windows 7 64-bit thanks

  • XuFLeS
    Posted at 12:13 pm, December 11, 2009

    Perfect solution, thanks very much W7 Running

  • Joe
    Posted at 1:46 pm, December 30, 2009

    Worked like a charm (on x64). Thanks.

  • Kevin
    Posted at 10:45 pm, January 20, 2010

    I was pointed here claiming this fix was for Win7 x64, but I can vouch for the fact that it also helps in Win7 x86. We’ve set up several USB-Serial adapters in windows 7 32-bit with no issues, but a particular brand kept going Code 10.

    So this fix also helps this problem in 32-bit Win7.

  • Hammad Naeem
    Posted at 11:30 am, January 21, 2010

    Thanks Bro…..It works for me…..Thank you very much…

  • Adelson
    Posted at 1:03 pm, January 29, 2010

    Thank you! You solved my problem!

    It works fine and instantly!

  • Howard Johnson
    Posted at 8:03 pm, February 18, 2010

    This driver which I got from the Prolific site worked for me: PL2303_Prolific_GPS_1013_20090319. Supposedly it fixes a problem with a GPS device, but I am using it successfully for a USB to Serial adapter.

  • Patrick Eradus
    Posted at 6:06 am, March 19, 2010

    thank you!

    this worked for me with my dealextreme order USB2.0 to serial converter.
    I use windows 7 64bits, connected to serial 1-wire hobbyboards hub.

  • fmarius
    Posted at 10:01 am, April 1, 2010

    thanks! worked for me to . win7 32 bits

  • D4T
    Posted at 8:58 am, April 7, 2010

    Wow, literally tried everything and this was the only driver that worked in Win 7 32bit). Many thanks!

  • Mike
    Posted at 11:29 am, May 3, 2010

    Thanks a lot! It works fine with my PL2303 based usb-to-serial adapter (Matsuyama CF215). I’m using Win7 x64 and the most recent Prolific’s drivers didn’t works.

  • Hamdi
    Posted at 8:22 am, May 12, 2010

    Thank you very much paul,

    I need this driver to run my Atmel AVR programmer…
    keep post any solution brother… ^_^

  • Ricepig
    Posted at 4:37 pm, June 26, 2010

    It works for me!
    Thank you very much!
    I’m using Win7 x64 and the most rent drivers(1210) did not work.

  • Mike142sl
    Posted at 11:00 am, June 28, 2010

    BIG Thanks. That all in one version has worked for me and my Win 7 64 bit laptop.
    It took a long time to find this and it’s a huge relief. Well done for finding it and posting the solution here.

  • Fredrik
    Posted at 3:45 pm, September 30, 2010

    I was going insane. You saved me. Thanx!!!!!!!!

  • Piyush Laad
    Posted at 1:54 am, October 10, 2010

    Thank you very much bro.. its working..

  • Jason T
    Posted at 10:37 am, October 26, 2010

    I too was getting the same error, this fix worked for me

    Win7 64bit Pro


  • Oleksiy Petrov
    Posted at 4:48 pm, November 11, 2010

    Win7 64bit Ent
    Not resolved
    Error 01

  • Posted at 1:55 am, December 6, 2010

    So thanks.it was a very big help.

  • Vik
    Posted at 7:52 pm, December 29, 2010

    Thank you so much !
    I was so tiredddd of looking for this driver

  • David
    Posted at 9:27 pm, March 14, 2011

    This link below is no longer valid. Anybody have the new link?


  • Saran
    Posted at 5:50 am, March 29, 2011

    Hi guys,

    The link provided, http://www.usglobalsat.com/download/546/win_drivers.zip is not working. Can anyone tell me some other link ???

    Thanks alot

  • Binzelli
    Posted at 4:01 am, May 11, 2011

    Solved for me: Win7 with Sitecom CN-104 V2 (older PL-2303 based cable)

    Seems like there are a lot of people experiencing problems with USB to Serial cables in Win7 or Vista. Searched all over the internet and found tons of driver (ser2pl(64).sys) versions ranging from to, but despite all the efforts none worked for me and looking at all the posts here, there still are quite some people who can’t get it to work.

    But luckily I found a solution that works for me and I hope it helps others too !

    On the website of ICIDU.com (who amongst others sell USB to serial cables), I found 32 bit Vista and Win7 drivers. The version of the ser2pl(64).sys is, which seems to me the first/oldest version I have found so far. And guess what: IT WORKS !

    I first uninstalled ánd deleted the old drivers and then updated the drivers (Update driver > Browse my computer for driver software > Browse) with the ones I found here:


    After a few seconds I got a “This device is working properly” and it works like a charm !

    Hope this solves some of your problems too !!

  • OnHEL
    Posted at 10:23 pm, June 7, 2011

    Used this driver for my Windows 7 64 Bit, only one that worked for me, all others just gave me Code 10. Happily telnetting right now :o)


  • Ikhwan
    Posted at 4:46 am, June 13, 2011

    It really works, great !!!!!!! Thank you very much !!!!

  • Posted at 6:12 pm, July 29, 2011

    I’ve been trying to get into a phone server for HOURS and this USB to Serial is what I needed. After all the searching for correct drivers for win7 x64..FINALLY Binzelli’s suggestion worked!!

    Use the drivers located here:


  • plopoi
    Posted at 5:12 am, August 8, 2011

    Hello all,

    and … Thx to you M. Binzelli this driver works very fine for me on W7-64 .

    Thx thx thx !

  • Sherif
    Posted at 8:49 pm, September 8, 2011


    It is working now Win7 64b.

    Many thanks to OnHEL this driver is working fine.

  • Yohan
    Posted at 4:21 am, September 19, 2011

    Binzelli and OnHel..


    Prolific really need to change their site!when you get code 10 error, they say its an error in the cable!

  • Martin
    Posted at 10:29 am, October 4, 2011

    The icidu.com link worked for me on Win7 Enterprise 32-bit, no more Code 10! The Prolific site appears to be down right now (code 500) but it’s a waste of space anyway. Cheers for the link!

  • Peter
    Posted at 2:11 pm, October 12, 2011


    Thanks a bunch, its on the eve of my project presentation day and almost formatted my computer. You saved me alot of inconviniences. Open source rocks!

  • Diego
    Posted at 6:02 pm, October 12, 2011

    With the Isidu driver
    Windows 7 Enterprice 64 Bit

  • Jeff
    Posted at 3:29 am, November 12, 2011

    Link is dead and 404’ing.

  • DFireman
    Posted at 7:48 am, November 14, 2011

    Installed perfectly on on Win7 32bits.

  • Shige
    Posted at 11:49 pm, November 22, 2011


    At last I could installed the correct driver by your suggestion.
    The error message I encounterd was [Can’t copy Inf file. Faled to install] which is different from the others here, but your method worked !
    Thanks you and ICIDU.com.

  • me
    Posted at 10:27 pm, April 11, 2012

    update icidu.com link:

    and/or, search for PL2303_Prolific_GPS_AllInOne_1013.exe

  • bring
    Posted at 8:03 pm, May 21, 2012

    Yes! Finally got it working with the version from the icidu site. Thanks everyone!

    I was getting very frustrated trying all different drivers and following dead links 😛

  • Louis
    Posted at 10:43 pm, June 14, 2012

    That Last one works….the all in one
    win7–64 the cd driver didn’t work
    id did worked with the all in one!

  • pustelnik
    Posted at 5:36 am, November 14, 2012

    Thx, It works 🙂

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